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Target intelligence / Profile preview
Killer cell lectin-like receptor subfamily B member 1C (Klrb1c)
- Target
- Klrb1c
- Molecular classification
- Receptor, C-type lectin-like receptor, Type II transmembrane protein
01
Overview
Killer cell lectin-like receptor subfamily B member 1C (Klrb1c, also known as NK1.1 or NKR-P1C) is a mouse type II transmembrane protein and member of the C-type lectin-like receptor family. Expressed on the surface of natural killer (NK) cells and a subset of T cells (notably NKT cells), Klrb1c serves as a marker for these populations in certain mouse strains (e.g., C57BL/6). The receptor participates in recognition of endogenous ligands, transducing activating signals that enhance NK cell cytotoxicity through calcium flux and downstream pathways. Its human paralog is KLRB1 (CD161). Klrb1c is frequently used as a marker in immunological studies but is also functionally implicated in immune regulation, including infection, inflammation, and anti-tumor responses[5][6][7][8][10].
- Other names
- NK1.1NKR-P1C
02
Mechanism of action
Modulation of immune cell cytotoxicity upon receptor engagement Calcium mobilization and downstream cell signaling upon cross-linking
03
Biological functions
Immune responseSignal transductionRegulation of NK cell cytotoxicityCo-stimulatory or inhibitory modulation of lymphocytes
04
Disease associations
InfectionInflammationCancer (influence on tumor immunity)Other (autoimmunity, immune surveillance)
05
Safety considerations
Targeting could dysregulate NK cell activity, risk of altered immune surveillance, inflammation, or autoimmunity if modulated incorrectly (inferred from role in immune regulation)
06
Biomarkers
NK1.1 (Klrb1c) is widely used as a murine NK cell marker in laboratory research
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