Killer cell lectin-like receptor subfamily C member 2 (KLRC2 (NKG2C))

Killer cell lectin-like receptor subfamily C member 2 (KLRC2), also known as NKG2C, is a type II integral membrane protein and member of the C-type lectin-like family of natural killer (NK) cell receptors[1][3][4]. Expressed primarily on NK cells, NKG2C forms heterodimers with CD94 to create the CD94/NKG2C activating receptor complex, which recognizes the non-classical MHC class I molecule HLA-E on the surface of potential target cells. Upon binding to HLA-E, NKG2C transmits intracellular activation signals via the DAP12 adapter protein, resulting in NK cell activation and cytotoxic responses[1][2][3]. NKG2C+ NK cells are notably expanded following human cytomegalovirus (CMV) infection, where they acquire memory-like properties and enhanced effector functions[2][3][4]. Genetic deletion or polymorphism of KLRC2 is relatively common in the population and is associated with variable susceptibility to viral infections and immune modulation[4]. KLRC2 is a key regulator of immune surveillance and adaptive features within NK cells, with roles in infection, cancer immunology, and possibly in maternal-fetal tolerance[1][3][4].

Other names

NKG2CNKG2-C type II integral membrane proteinCD159cNKG2-CNK cell receptor CNKG2-C-activating NK receptornatural killer cell receptor G2-CCD159 antigen-like family member C

- Cell activation through recognition of HLA-E on target cells - Intracellular signal transduction by DAP12 adapter recruitment (activating NK cell cytotoxicity)