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Killer immunoglobulin-like receptor 2DL1
- Molecular classification
- Receptor, Type I transmembrane glycoprotein
01
Overview
Killer immunoglobulin-like receptor 2DL1 (KIR2DL1) is a type I transmembrane glycoprotein expressed on natural killer (NK) cells and some T cell subsets. It regulates NK cell activity by interacting with MHC-I molecules, specifically HLA-C alleles bearing the C2 epitope. Upon ligand binding, KIR2DL1 transduces an inhibitory signal that suppresses NK cell cytotoxicity, preventing lysis of healthy self-cells. Variations in the *KIR* gene cluster are associated with susceptibility or resistance to infections, autoimmune diseases, cancer progression, and outcomes in transplantation settings.
- Other names
- CD158aNKAT1p58.1KIR221
02
Mechanism of action
Inhibits NK cell cytotoxicity upon binding to HLA-C alleles with C2 epitope via ITIM signaling.
03
Biological functions
Immune responseInhibitory regulation of NK cell cytotoxicity
04
Disease associations
InfectionAutoimmune diseasesCancer progressionTransplantation outcomes
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