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Target intelligence / Profile preview
Killer immunoglobulin-like receptor 2DL3 (KIR2DL3)
- Target
- KIR2DL3
- Molecular classification
- Receptor, Transmembrane glycoprotein
01
Overview
Killer immunoglobulin-like receptor 2DL3 (KIR2DL3) is an inhibitory receptor expressed on NK cells and some T cells. It binds to HLA-C allotypes (Cw1, Cw3, Cw7) and transmits inhibitory signals to prevent NK cell activation and lysis of target cells. It plays a role in immune regulation and self-tolerance. Dysregulation can contribute to pathological conditions such as cancer or impaired immune responses. Clinical studies have shown associations between certain KIR/HLA combinations—including those involving KIR2DL3—and outcomes in infectious diseases like hepatitis C virus infection clearance.
02
Mechanism of action
Inhibits NK cell activation/lysis via ITIM signaling upon binding to HLA-C ligands.
03
Biological functions
Immune responseInhibitory signalingRegulation of NK cell activityMaintenance of self-tolerance
04
Disease associations
InfectionCancerImmune dysregulation
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