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Target intelligence / Profile preview
Kin of IRRE-like protein 1 (KIRREL1)
- Target
- KIRREL1
- Molecular classification
- Cell adhesion molecule, Immunoglobulin superfamily member, Transmembrane protein, Signaling protein
01
Overview
KIRREL1 (Kin of IRRE-like protein 1), commonly called NEPH1, is a transmembrane cell adhesion molecule belonging to the immunoglobulin superfamily. It is primarily expressed in kidney podocytes, maintaining the structure of the glomerular filtration barrier and podocyte foot processes via specialized cell-cell junctions called the slit diaphragm. KIRREL1 interacts with cytosolic proteins such as podocin and nephrin and is essential for selective filtration of blood. It also modulates the Hippo signaling pathway by recruiting SAV1 to sites of cell-cell contact and acting as a feedback regulator to inhibit YAP/TAZ-mediated proliferation. Dysregulation or mutation of KIRREL1 is associated with nephrotic syndromes and may play a role in cancer by impacting Hippo signaling[1][2][3][6].
- Other names
- NEPH1Kirre like nephrin family adhesion molecule 1Kin of IRRE-like protein 1KIRRELNephrin-like protein 1NPHS23kin of irregular chiasm-like protein 1nephrin related
02
Mechanism of action
null
03
Biological functions
Cell-cell adhesionGlomerular filtration barrier maintenancePodocyte architecture stabilizationRegulation of Hippo signaling pathwayRecruitment of SAV1 to plasma membraneInhibition of YAP/TAZ activation and cell proliferation
04
Disease associations
Nephrotic syndrome, type 23Glomerular filtration defectsCancer (due to Hippo/YAP dysregulation)Other renal disorders (based on podocyte function)
05
Safety considerations
Potential impact on renal filtration function if inhibited or mutatedPossible contribution to unchecked cell proliferation if signaling pathway is disruptedTissue-specific expression—safety profile may depend on podocyte/relevant tissue targeting
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