Kinase D-interacting substrate of 220 kDa (KIDINS220)

Kinase D-interacting substrate of 220 kDa (KIDINS220, also known as ARMS) is a highly conserved transmembrane scaffolding protein expressed predominantly in the brain, neuroendocrine, and immune cells[1][2][4]. It contains multiple ankyrin repeats, a proline-rich domain, SAM-like domain, kinesin-interacting motif (KIM), and a PDZ ligand motif[2]. KIDINS220 anchors neurotrophin receptors (TrkA/B/C, p75 NTR) and participates in intracellular signaling cascades crucial for neuronal survival, differentiation, dendritic maturation, synaptic plasticity, heart development, and immune cell maturation[1][3][4][5]. Mutations in KIDINS220 are causative for SINO syndrome and have been linked to Alzheimer's disease, asthma, and cancer[2][5]. KIDINS220 interacts with the kinesin-1 motor complex for intracellular trafficking along neurites, and disruption impairs neurotrophin signaling and neuronal growth[1][4]. Loss of KIDINS220 leads to apoptosis in sensory ganglia, defective heart and brain development, and postnatal lethality in animal models[3][4][5]. There are no approved drugs directly targeting KIDINS220, and therapeutic modulation poses notable safety risks due to its essential biological functions.

Other names

Ankyrin repeat-rich membrane-spanning protein (ARMS)KIAA1250SINO (rare: SINO syndrome context)VENARGKinase D-interacting substrate 220kDaKIDINS220/ARMS

Not applicable for drugs targeting KIDINS220, as no targeted drugs are reported. Biological mechanism involves scaffolding and signal integration for neurotrophin and ephrin receptor-mediated cascades, including MAPK pathway activation[1][2][4].