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Target intelligence / Profile preview
Kinase Insert Domain-Containing Receptor (KDR)
- Target
- KDR
- Molecular classification
- Receptor Tyrosine Kinase, Type III/IV receptor tyrosine kinase
01
Overview
The kinase insert domain-containing receptor (KDR), also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a receptor tyrosine kinase that mediates the effects of vascular endothelial growth factor (VEGF) on endothelial cells. It plays a critical role in angiogenesis and vasculogenesis by promoting endothelial cell proliferation, migration, and survival. Its activation by VEGF-A leads to receptor dimerization and autophosphorylation, activating downstream signaling pathways. Dysregulation of KDR is implicated in cancer and diabetic vasculopathy, making it a validated therapeutic target. Blockade of KDR function is a strategy employed against cancers dependent on neovascularization.
- Other names
- VEGFR-2CD309Flk1
02
Mechanism of action
Inhibition of KDR signaling
03
Biological functions
AngiogenesisEndothelial cell proliferationEndothelial cell migrationEndothelial cell survivalSignal transduction
04
Disease associations
CancerDiabetic vasculopathy
05
Safety considerations
Potential for off-target effectsDevelopment of resistance
06
Biomarkers
Q472H variant (NSCLC)KDR phosphorylation levels
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