Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1)

Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1) is a protein found mainly in neuronal and endothelial cells and is involved in regulating signal transduction pathways including the p53 and MAPK pathways. KNDC1 serves as a scaffold or protein-protein interaction module rather than a catalytic kinase; it is implicated in processes such as cellular senescence, cell proliferation, dendritic development in neurons, and angiogenesis. Knockdown of KNDC1 in endothelial cells promotes proliferation, delays senescence, and enhances tube formation by affecting the p53-p21-p16 pathway and ERK signaling, while overexpression accelerates senescence via a p53–reactive oxygen species positive feedback loop[1][2]. KNDC1 is considered a candidate therapeutic target for modulating cellular aging and possibly for treating age-related vascular or neuronal diseases. No direct pharmacological agents or biomarkers specific to KNDC1 are currently established in the literature.

Other names

KNDC1C10orf23KIAA1768RASGEF2VKINDKIND domain-containing protein 1v-KINDCerebral protein 9Very-KINDProtein very KINDRas-GEF domain-containing family member 2RasGEF domain family, member 2kinase non-catalytic C-lobe domain containing 1bB439H18.3FLJ25027

Modulation of p53 signaling pathway (senescence induction), Regulation of MAPK (ERK) pathway for cell proliferation, p53–ROS positive feedback loop activation