Target intelligence / Profile preview

Kinase of the Outer Chloroplast Membrane 1 (KOC1)

Target: KOC1
Molecular classification: Enzyme, Protein Kinase, Serine/Threonine Kinase

Overview

KOC1 is a serine/threonine protein kinase in Arabidopsis thaliana that regulates plastid protein import by phosphorylating import receptors like TOC159. It is located on the outer chloroplast membrane and is crucial for efficient preprotein import and chloroplast development. Note: In human cancer research, "KOC1" can refer to IGF2BP3, a tumor antigen used in cancer vaccines. This is distinct from the plant protein.

Biological functions

Protein phosphorylationRegulation of protein importChloroplast biogenesisPlastid protein import machinery

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