Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kinesin Family Member 11 (KIF11)
- Target
- KIF11
- Molecular classification
- Motor protein, Kinesin superfamily, ATPase, Enzyme
01
Overview
KIF11 is a molecular motor protein essential for mitosis. It belongs to the kinesin superfamily and plays a critical role in mitotic spindle formation by cross-linking and sliding apart anti-parallel microtubules. Overexpression or dysregulation of KIF11 is implicated in several cancers, making it a promising target for anticancer therapies. Small-molecule inhibitors targeting KIF11’s motor domain are under investigation as potential chemotherapeutics.
- Other names
- Eg5Kinesin-5BimCN-2[2]
02
Mechanism of action
KIF11 assembles into a bipolar homotetramer that binds to overlapping regions of anti-parallel microtubules. Through its plus-end-directed motility powered by ATP hydrolysis at its motor domains, it slides these microtubules apart—an action critical for establishing a functional bipolar spindle during metaphase[2][3][6].
03
Biological functions
Mitotic spindle formationChromosome positioningCentrosome separationMaintenance of spindle bipolarityMicrotubule slidingCell divisionNeuronal development
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the involvement of kinesins in other cellular processesToxicity associated with mitotic disruption in non-cancerous cells
Beyond the preview
Go deeper on Kinesin Family Member 11 (KIF11).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kinesin Family Member 11 (KIF11).