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Kinesin family member 13B (KIF13B)
- Target
- KIF13B
- Molecular classification
- Kinesin superfamily protein, Microtubule-associated motor protein, Protein coding gene, Other
01
Overview
Kinesin family member 13B (KIF13B) is a microtubule-based motor protein belonging to the kinesin superfamily, encoded by the KIF13B gene in humans. It plays a central role in intracellular cargo transport, especially trafficking of proteins important for neuronal polarity and axon formation. KIF13B also acts as a molecular scaffold, regulating key signaling pathways such as PI3K/AKT and influencing processes like myelination in both the peripheral and central nervous systems. Its activity is important for correct nervous system development, and mutations are associated with neurodevelopmental syndromes and sensorineural deafness. While KIF13B is not currently a therapeutic drug target, its critical signaling and transport functions have been implicated in disease mechanisms[1][2][3][4][6].
- Other names
- Kinesin-like protein KIF13BGAKINKIAA0639Kinesin-like protein GAKINGuanylate kinase associated kinesinkinesin 13B
02
Biological functions
Microtubule-based transportAxonogenesis and neuronal polarityRegulation of myelination (in PNS and CNS)Scaffold and signaling molecule functions (e.g., PI3K/AKT pathway modulation)Intracellular trafficking of membrane-associated guanylate kinases (MAGUKs)Interaction with 14-3-3 proteins and protein kinases
03
Disease associations
Neurodevelopmental disease (e.g., NESCAV syndrome)Deafness (autosomal recessive 84A)Possible involvement in nervous system myelination disordersOther
04
Safety considerations
Not established as a therapeutic target, so safety has not been characterizedPotential concerns if considered for targeting could include effects on neuronal polarity, axonal transport, or myelination
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