Kinesin family member 16B (KIF16B)

Kinesin family member 16B (KIF16B) is a plus end-directed microtubule-dependent motor protein of the kinesin-3 family that primarily mediates the *anterograde* transport of early endosomes along microtubules[1][2]. KIF16B contains a PX (phox homology) domain that binds strongly to phosphatidylinositol-3-phosphate (PtdIns(3)P) on endosomal membranes, facilitating endosome tethering and motility[3][5]. Through this mechanism, KIF16B regulates endosome positioning and the balance between *receptor recycling* and *degradation* (notably EGFR and FGFR), impacting signal transduction, membrane trafficking, and cellular polarization in various systems including epithelial cells and neurons[1][2][4]. Disruption of KIF16B leads to mislocalization and aggregation of endosomes, causing defects in receptor trafficking and neuronal function. The protein has been mechanistically linked to processes relevant for development and disease, but is not currently a known drug target, and no direct drug interactions, mechanistic inhibitors, or established safety concerns have been reported in the literature to date[2][1].

Other names

C20orf23KIAA1590SNX23FLJ20135dJ971B4.1Sorting nexin-23sorting nexin 23KISC20ORFkinesin-like protein KIF16Bkinesin motor proteintestis secretory sperm-binding protein Li 201a