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Kinesin family member 19 (KIF19)
- Target
- KIF19
- Molecular classification
- Motor protein, Enzyme (ATPase), Cytoskeletal protein
01
Overview
Kinesin family member 19 (KIF19) is a microtubule-dependent motor protein that uses ATP hydrolysis to drive its movement along microtubules and is involved in regulating cilia length by mediating depolymerization of microtubules at the tips of motile cilia. It contributes to various cellular processes including cell movement and organization. KIF19 has been implicated in cancer metastasis and influences cell-cell and cell-matrix interactions. Diseases associated with mutations or dysregulation of KIF19 include nonimmune hydrops fetalis and congenital megabladder[1][2][3][7][8].
- Other names
- Kinesin-like protein KIF19KIF19Akinesin family member 19AFLJ37300RGD1559936
02
Mechanism of action
Depolymerization of microtubules at ciliary tips
03
Biological functions
Microtubule-based movementRegulation of cilia lengthATP hydrolysisPlus-end-directed microtubule motor activityCilium-dependent processes
04
Disease associations
Cancer (implicated in metastasis)Hydrops fetalis, nonimmuneCongenital megabladder
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