Kinesin family member 1C (KIF1C)

Kinesin family member 1C (KIF1C) is a dimeric, plus-end directed microtubule motor from the kinesin-3 family, facilitating transport of vesicles, lysosomes, and integrins within cells. KIF1C is regulated by protein interactions that modulate its autoinhibition and motor activity; notably, Rab6A binding controls microtubule association, while adaptors such as HOOK3 and PTPN21 enable cargo-dependent activation. Loss-of-function mutations in KIF1C underlie the neurological disorder spastic ataxia 2 (SPAX2), characterized by progressive spasticity, cerebellar dysfunction, and ataxia, with prominent involvement of the lower limbs and cerebellar neurons. Physiologically, KIF1C supports directional cargo movement, Golgi stability, and immune antigen presentation in specific cell types. There is no evidence of misspelling or ambiguity in the provided nomenclature. No small molecule or biologic drugs are currently known to therapeutically modulate KIF1C in clinical practice. Genetic testing for KIF1C variants serves as a diagnostic tool and biomarker for related hereditary neurodegenerative disorders.

Other names

Kinesin-like protein KIF1CKIAA0706LTXS1SATX2SAX2SPAX2SPG58spastic ataxia 2 (autosomal recessive)

not applicable (no drugs; mechanisms described for physiological partners involve regulation by interaction and release from autoinhibition via proteins such as PTPN21 and HOOK3)