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Target intelligence / Profile preview
Kinesin family member 20A (KIF20A)
- Target
- KIF20A
- Molecular classification
- Motor Protein, Kinesin
01
Overview
KIF20A is a microtubule-based motor protein that plays key roles during mitosis and cytokinesis by facilitating proper chromosome segregation and cell division. It mediates transport of vesicles from the Golgi apparatus and interacts with RAB6A GTPase for vesicle trafficking. It is overexpressed in various cancers, including glioma and melanoma, and is considered a tumor-associated antigen involved in cancer cell growth and survival. KIF20A is explored as an immunotherapy target due to its overexpression on tumor cells but limited expression on normal tissues.
- Other names
- MKLP2RAB6KIFLRCM6
02
Biological functions
Microtubule-based transportMitosis/CytokinesisGolgi-vesicle traffickingCell cycle regulationVesicle transport
03
Disease associations
CancerFamilial restrictive cardiomyopathy type 6
04
Biomarkers
Overexpression in gliomaOverexpression in melanoma
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