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Target intelligence / Profile preview
Kinesin family member 20A protein (KIF20A)
- Target
- KIF20A
- Molecular classification
- Kinesin, Motor Protein, ATPase
01
Overview
KIF20A is a mitotic kinesin essential for proper cell division. It plays critical roles in microtubule bundle formation, midbody abscission during cytokinesis, and regulation of cytokinesis through recruitment of key proteins like PLK1. Overexpression or dysregulation of KIF20A has been observed in various cancers, making it a promising anti-cancer drug target. The L6 loop within the N-terminal motor domain contains an unusually long insertion compared to other kinesins, modulating both structural conformation and functional properties and offering a potential druggable site.
02
Mechanism of action
Inhibition of KIF20A disrupts cancer cell division by interfering with cytokinesis mechanisms
03
Biological functions
Cytokinesis regulationMicrotubule bundle formationIntracellular transportCell division
04
Disease associations
Cancer
05
Safety considerations
Potential disruption of normal cell division in healthy tissues
06
Biomarkers
KIF20A overexpression as a marker for cancer
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