Kinesin family member 22 (KIF22)

Kinesin family member 22 (KIF22) is a microtubule-dependent molecular motor protein that plays a critical role in mitosis by generating polar ejection forces, enabling chromosome congression and alignment during prometaphase and metaphase, and ensuring accurate spindle-mediated chromosome segregation. The protein contains a C-terminal DNA-binding domain and exhibits both microtubule motor and DNA interaction functions. KIF22 regulates key steps in cell cycle progression, particularly the G2/M transition, through direct transcriptional activation of relevant cell cycle regulators like CDC25C and CDCA3. Overexpression of KIF22 is associated with increased cell proliferation and poor prognosis in several cancers (multiple myeloma, bladder cancer, breast cancer, melanoma), and mutations in the gene cause certain developmental skeletal disorders. As a result, KIF22 is considered a potential therapeutic target, although currently, there are no known drugs that directly target this protein in the clinic[1][2][3][4][5][6][7].

Other names

KIDKNSL4OBPOBP-1OBP-2SEMDJL2kinesin-like protein KIF22kinesin-like DNA-binding proteinkinesin-like protein 4A-328A3.2oriP binding proteinorigin of plasmid DNA replication-binding protein

Modulation of microtubule dynamics to control chromosomal movement and alignment during mitosis Transcriptional regulation of cell cycle genes (e.g., CDC25C, CDCA3)