Kinesin family member 24 (KIF24)

Kinesin family member 24 (KIF24) is a microtubule-based motor protein in the kinesin-13 subfamily that localizes to the mother centriole and acts as a negative regulator of ciliogenesis by depolymerizing centriolar microtubules and restricting aberrant cilia formation[1][4]. KIF24 interacts with centrosomal proteins (notably CP110 and Cep97) and is essential for the dynamic assembly and disassembly of primary cilia, a process critical for proper cell cycle progression and signaling. NEK2-mediated phosphorylation activates KIF24 during the S/G2 phases, promoting cilium disassembly and preventing cilia regrowth in dividing cells, a mechanism implicated in the control of cell proliferation and, when dysregulated, in certain cancers[1][3][4]. Disease relevance is supported by genetic evidence linking KIF24 variants to frontotemporal lobar degeneration and skeletal dysplasias, manifesting features of ciliopathies and providing insight into the biological importance of centriolar and ciliary dynamics[1][4]. No drugs have been reported to target KIF24 directly.

Other names

Kinesin-like protein KIF24C9orf48bA571F15.4FLJ10933FLJ43884

Not applicable (no known drugs)