Kinesin family member 25 (KIF25)

Kinesin family member 25 (KIF25) is a minus-end directed microtubule motor protein of the kinesin-14 subfamily, expressed ubiquitously in human tissues[1][3][4][5]. It operates as a tetramer and is localized to centrosomes throughout the cell cycle[7]. KIF25 acts as a negative regulator of centrosome separation, tethering duplicated centrosomes together during interphase and helping to maintain a centered nucleus, thereby ensuring proper spindle orientation at mitosis onset[1][4][7]. Loss of KIF25 results in premature centrosome separation, nuclear mispositioning, and defects in spindle orientation, which may impact accurate chromosome segregation[7]. KIF25 has also been implicated, more generally as a member of the kinesin family, in cancer progression and as a possible contributor to disease phenotypes related to cell division and centrosomal defects[2][4]. There are no reported drugs directly targeting KIF25, and its precise role in human diseases, as well as its potential as a clinical biomarker or safety liabilities, remain underexplored.

Other names

KNSL3Kinesin-like protein KIF25Kinesin-like protein 3kinesin-14