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Target intelligence / Profile preview
Kinesin family member 2C (KIF2C)
- Target
- KIF2C
- Molecular classification
- Kinesin superfamily, Kinesin-13, Enzyme
01
Overview
KIF2C, also known as MCAK, is a kinesin-13 family member essential for regulating microtubule dynamics and chromosome segregation during cell division. It functions as a microtubule depolymerase at kinetochores, playing a crucial role in proper anaphase chromosome segregation. Overexpression of KIF2C is observed in many cancers, promoting tumor progression and metastasis. Due to its role in maintaining chromosomal stability and its overexpression in tumors, KIF2C is considered a potential therapeutic target.
- Other names
- Mitotic centromere-associated kinesinMCAK
02
Mechanism of action
Microtubule depolymerization at kinetochores, regulation of chromosome segregation.
03
Biological functions
Microtubule depolymerizationRegulation of microtubule dynamicsChromosome segregationCell cycle
04
Disease associations
CancerChromosomal instability
05
Safety considerations
Potential for chromosomal instabilityImportance for normal mitotic processes necessitates careful targeting
06
Biomarkers
KIF2C overexpression in tumors
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