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Kinesin light chain 2 (KLC2)

Target: KLC2
Molecular classification: Motor protein subunit, Cargo adaptor (microtubule motor protein complex), Other (“Kinesin-associated protein” if more granular class is needed)

Overview

Kinesin light chain 2 (KLC2) is a subunit of the kinesin-1 motor protein complex, which is essential for intracellular transport along microtubules[2][3][4]. Kinesin-1 is composed of two heavy chains and two light chains; KLC2 functions as one of the light chains[3]. The protein mediates binding of cargo to the kinesin-1 complex—its tetratricopeptide repeat (TPR) domains recognize specific peptide motifs on cargo adapters, and it helps regulate the activation and motility of the kinesin-1 motor[1][4][5]. KLC2 is ubiquitously expressed and required for proper vesicle/organelle trafficking and lysosomal positioning[2][4][6]. Mutations in KLC2 have been implicated in human diseases such as hereditary spastic paraplegia, SPOAN syndrome, and optic atrophy with neuropathy[2]. Currently, KLC2 is not considered a direct therapeutic drug target, and no drugs or specific inhibitors have been identified for it[2].

Other names: KLC 2FLJ12387KLC2_HUMANkinesin light chain 2

Biological functions

Organelle transportVesicle transportCoupling cargo to kinesin heavy chainRegulation of kinesin-1 motor activityLysosomal positioning

Disease associations

Neurodegenerative disease (linked to hereditary spastic paraplegia, SPOAN syndrome, optic atrophy, neuropathy)Other (defects in intracellular transport can underlie a variety of neurological conditions)

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