Kinesin light chain 4 (KLC4)

Kinesin light chain 4 (KLC4) is a subunit of the kinesin-1 motor protein complex and plays a critical role in microtubule-based transport within cells. KLC4 functions as a cargo adaptor, specifying which cellular cargoes are transported by the kinesin-1 motor along microtubules, particularly in neurons. It is essential for the development of proper neuronal morphology, axon branching, and compartmentalization, as well as for behaviors associated with sensory response and stress in model organisms. Mutations in KLC4 have been linked to a spectrum of neurodevelopmental and neurodegenerative disorders, such as hereditary spastic paraplegia, retinitis pigmentosa, sensorineural hearing loss, and demyelinating neuropathy. While not recognized as a classic drug target or receptor, research compounds such as Kinesore can modulate KLC4 function to explore its cellular roles[1][2][3][4].

Other names

KLC4KNSL8KLC 4bA387M24.3kinesin-like protein 8CONDRHN

Disrupts KLC-cargo adaptor interactions and modulates kinesin-mediated microtubule dynamics[2]