Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kinesin-like protein KIF11 (Eg5)
- Target
- Eg5
- Molecular classification
- Motor protein, Kinesin superfamily
01
Overview
Kinesin-like protein KIF11 (Eg5) is a motor protein essential for mitosis in human cells. It establishes bipolar spindle formation during cell division by cross-linking anti-parallel microtubules. Inhibition or loss of function leads to monopolar spindles and cell cycle arrest at mitosis, making it an active anticancer drug target. Small-molecule inhibitors like GSK‑1 trap Eg5 on the microtubule lattice, blocking its function.
- Other names
- kinesin-5BimCN-2kinesin-like spindle protein HKSPKNSL1TRIP-5Thyroid receptor-interacting protein 5TRIP5
02
Mechanism of action
Inhibition of KIF11 traps Eg5 on the microtubule lattice, stabilizing an "ATP-like" conformation without nucleotide bound, blocking its function allosterically, leading to failed bipolar spindle formation and cell cycle arrest.
03
Biological functions
ATP bindingATP-dependent microtubule motor activityPlus-end-directed movement on microtubulesProtein complex bindingKinase bindingCell divisionMitotic nuclear divisionChromosome segregationMicrotubule-based movementMitotic centrosome separationSpindle assembly & organizationRegulation of centrosome separationBlood coagulationAntigen processing via MHC class II presentation
04
Disease associations
Cancer
05
Safety considerations
Disruption of cell division may affect proliferating cells.
06
Interacting drugs
GSK‑1
Beyond the preview
Go deeper on Kinesin-like protein KIF11 (Eg5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kinesin-like protein KIF11 (Eg5).