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Target intelligence / Profile preview
Kinesin family member 18A (KIF18A)
- Target
- KIF18A
- Molecular classification
- Motor Protein, Kinesin superfamily
01
Overview
KIF18A is a plus-end directed microtubule motor protein crucial for cell division, particularly in chromosome congression and spindle dynamics. It is implicated as an oncogenic driver in several cancers and is being explored as a therapeutic target with small molecule inhibitors like Sovilnesib, which inhibits ATPase activity and impairs tumor cell proliferation.
- Other names
- Kinesin-like protein KIF18A
02
Mechanism of action
Allosteric inhibition via alpha‑4 helix; microtubule depolymerization
03
Biological functions
Mitotic spindle dynamicsChromosome congressionMicrotubule depolymerizationCell divisionIntracellular transport
04
Disease associations
CancerHepatocellular carcinoma (HCC)Lung adenocarcinomaIntellectual disability
05
Safety considerations
Potential toxicity to normal cells, although mouse models suggest some selectivity for tumor cells.The impact of KIF18A inhibition on male fertility needs consideration.
06
Interacting drugs
Sovilnesib
1 more in the full profile.
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