Kinesin-like protein KIF1A (KIF1A)

Kinesin-like protein KIF1A is a neuron-specific, microtubule-based motor protein encoded by the KIF1A gene in humans[1]. It belongs to the kinesin-3 subfamily and primarily mediates long-distance anterograde axonal transport of membranous cargoes, including synaptic vesicle precursors and dense core vesicles, by hydrolyzing ATP to generate mechanical force and “walk” along microtubules[1][3]. KIF1A is essential for neuronal survival, synaptic transmission, brain development, and higher cognitive function[1]. Disruption or mutation of KIF1A leads to severe neurodevelopmental and neurodegenerative disorders, collectively known as KIF1A-associated neurological disorders (KAND), characterized by spasticity, intellectual disability, and peripheral neuropathy[2][4][5]. Mechanistically, KIF1A is distinguished by high processivity and rapid movement powered by structural features such as its motor domain and the lysine-rich K-loop, allowing efficient delivery of cargo throughout the neuron[3][5]. While KIF1A is a recognized therapeutic target due to its role in neuronal health and disease, clinically relevant modulators have not yet been described in the literature[5].

Other names

KIF1AATSVC2orf20hUnc-104UNC104Axonal transporter of synaptic vesiclesMicrotubule-based motor KIF1AUnc-104- and KIF1A-related proteinHSN2CMRD9NESCAVSSPG30SPG30ASPG30B