Kinesin-like protein KIF3A (KIF3A)

Kinesin-like protein KIF3A is a component of the kinesin-2 complex—a microtubule plus end-directed motor protein complex responsible for the anterograde transport of vesicles, protein complexes, and organelles along microtubules[1][2]. KIF3A, functioning as a heterotrimer with KIF3B or KIF3C and the associated protein KAP3, is essential for the formation and maintenance of cilia and flagella, regulates crucial signaling pathways (notably Wnt/β-catenin), and plays a prominent role in the development, differentiation, and homeostasis of a wide array of tissues[1][2][3][5]. Mutations or dysregulation of KIF3A are implicated in the pathogenesis of polycystic kidney disease, multiple solid tumor types, organ fibrosis, and developmental anomalies, making it a key candidate for research in ciliopathies and cancer biology[2][3][5]. Direct therapeutic targeting is not currently established, but its biological significance is well recognized.

Other names

KIF3AKinesin family member 3AKinesin-like protein KIF3AKIF3FLA10KLP-20Microtubule plus end-directed kinesin motor 3Akinesin family protein 3A