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Kinetoplastid Proteasome
- Molecular classification
- Enzyme, Protease, Multisubunit enzyme complex
01
Overview
The kinetoplastid proteasome is a large, multisubunit enzyme complex found in kinetoplastid parasites, such as *Trypanosoma cruzi*, *Leishmania* spp., and *Trypanosoma brucei*. It plays a central role in protein degradation and turnover, essential processes for cell-cycle progression, apoptosis regulation, and overall parasite viability. Selective inhibitors have been developed that exploit structural differences between parasite and human proteasomes, making it a validated therapeutic target. Examples of such inhibitors include GNF6702 and LXE408.
02
Mechanism of action
Allosteric/catalytic inhibition at unique subunit interfaces
03
Biological functions
Protein degradationRegulation of cell cycleRegulation of apoptosisProtein turnover
04
Disease associations
Chagas diseaseLeishmaniasisSleeping sickness
05
Interacting drugs
GNF6702
2 more in the full profile.
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