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Kir3.2 Potassium Channel (GIRK2)
- Target
- GIRK2
- Molecular classification
- Ion Channel, Potassium Channel, Inwardly Rectifying Potassium Channel, Kir/GIRK family
01
Overview
Kir3.2, also known as GIRK2, is an inwardly rectifying potassium channel crucial for regulating neuronal excitability and maintaining resting membrane potential. It is activated by G-protein-coupled receptors (GPCRs), particularly those coupled to Gi/o proteins. Predominantly expressed in brain neurons, it mediates the inhibitory effects of neurotransmitters by hyperpolarizing neuronal membranes, reducing neuronal firing rates. Dysregulation or mutations are implicated in pain perception, addiction, mood regulation and other neurological disorders.
- Other names
- GIRK2KCNJ6G-protein-coupled inwardly rectifying potassium channel 2
02
Mechanism of action
Activation by Gβγ dimer released from Gi/o-coupled GPCRs leading to hyperpolarization of neuronal membranes.
03
Biological functions
Regulation of neuronal excitabilityMaintenance of resting membrane potentialMediates inhibitory neurotransmitter effectsControls neuronal firing rates
04
Disease associations
Pain perceptionAddiction behaviors (alcoholism/substance abuse)Mood regulationNeurological disorders
05
Interacting drugs
Opioids
5 more in the full profile.
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