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Target intelligence / Profile preview
Kirsten rat sarcoma viral oncogene homolog (KRAS) G12V mutant peptide-HLA-A*11 complex
- Molecular classification
- MHC Class I complex, Neoantigen, Peptide-HLA complex
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Overview
The KRAS G12V mutant peptide-HLA-A*11 complex is a molecular complex formed by a mutated KRAS-derived peptide (VVVGAVGVGK, with the G12V mutation) bound to the human leukocyte antigen HLA-A*11:01. This complex is presented on the cell surface and can be recognized by T cells, enabling targeted immune responses against tumor cells harboring this mutation. It serves as a neoantigen target for cancer immunotherapy, including adoptive cell therapy and vaccine development.
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Mechanism of action
T-cell mediated cytotoxicity upon TCR recognition
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Biological functions
Antigen presentationT-cell activationImmune responseTumor cell recognition
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Disease associations
CancerImmune evasion
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Safety considerations
Off-target T-cell activationCytokine release syndromeTumor lysis syndrome
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Biomarkers
KRAS G12V mutationHLA-A*11 expression
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