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Target intelligence / Profile preview
Kirsten rat sarcoma viral oncogene homolog (Mutant) (KRAS (Mutant))
- Target
- KRAS (Mutant)
- Molecular classification
- Small GTPase, RAS family, Oncogene
01
Overview
Kirsten rat sarcoma viral oncogene homolog (KRAS) is a gene encoding the K-Ras protein, a small GTPase that plays a central role in cell signaling pathways regulating proliferation, differentiation, and survival. KRAS mutations, particularly at codons 12, 13, and 61, lock KRAS in its active (GTP-bound) state, leading to continuous activation of proliferative and survival signaling pathways independent of external stimuli, driving uncontrolled cell division and tumorigenesis. Specific inhibitors have been developed targeting the KRAS(G12C) mutant.
- Other names
- K-Ras (Mutant)KRAS G12CKRAS G12DKRAS G12VKRAS G13KRAS Q61
02
Mechanism of action
Direct covalent inhibition of KRAS(G12C); inhibition of upstream activators (EGFR); inhibition of downstream effectors (RAF/MEK/ERK, PI3K/mTOR)
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalRegulation of downstream effectors (RAF-MEK-ERK, PI3K-AKT-mTOR)
04
Disease associations
CancerNon-small cell lung cancer (NSCLC)Pancreatic adenocarcinomaColorectal carcinomaUrogenital cancersNoonan syndromeCardiofaciocutaneous syndrome
05
Safety considerations
Resistance to targeted therapiesCompensatory pathway activationLimited efficacy of indirect targeting strategiesOff-target effects of inhibitors
06
Interacting drugs
KRAS(G12C) inhibitors (e.g., sotorasib, adagrasib)
4 more in the full profile.
07
Biomarkers
KRAS mutation status (e.g., G12C, G12D, G12V)KRAS protein expression
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