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Target intelligence / Profile preview
Kirsten rat sarcoma viral oncogene homolog G12V (KRAS G12V)
- Target
- KRAS G12V
- Molecular classification
- Small GTPase, Oncoprotein, Signaling protein
01
Overview
KRAS G12V is a specific point mutation in the KRAS gene where glycine at position 12 is replaced by valine. This mutation results in constitutive activation of the KRAS protein, leading to oncogenic signaling and tumorigenesis. It is prevalent in several cancer types, including pancreatic, colorectal, and lung cancer, and is associated with poor prognosis and resistance to EGFR-targeted therapies. Direct inhibition of KRAS G12V is challenging, but immunotherapeutic approaches are under investigation.
- Other names
- KRAS G12V mutationKRAS G12V mutant
02
Mechanism of action
Constitutive activation of KRAS signaling pathways, leading to uncontrolled cell growth and survival.
03
Biological functions
Signal transductionCell proliferationCell survivalMetabolic regulationRegulation of gene expression
04
Disease associations
CancerPancreatic cancerColorectal cancerNon-small cell lung cancer
05
Safety considerations
Poor prognosis associated with KRAS mutationsResistance to targeted therapiesTherapeutic challenges in developing direct inhibitors
06
Interacting drugs
Sotorasib (ineffective)
6 more in the full profile.
07
Biomarkers
Predictive biomarker for resistance to EGFR inhibitorsBiomarker for patient selection in clinical trials
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