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KISS1 receptor (KISS1R)
- Target
- KISS1R
- Molecular classification
- G protein-coupled receptor, GPCR, Class A peptide-GPCR
01
Overview
The KISS1 receptor (KISS1R), also known as GPR54, is a G protein-coupled receptor that plays a central role in reproductive physiology. Activation by kisspeptins triggers the release of GnRH, leading to the secretion of gonadotropins. It is also involved in metabolic regulation and acts as a metastasis suppressor in certain cancers. Mutations in KISS1R can cause hypogonadotropic hypogonadism.
- Other names
- GPR54Kisspeptin receptor
02
Mechanism of action
Activation of Gq/11 proteins, leading to PLC activation and downstream signaling cascades; β-arrestin-dependent ERK activation
03
Biological functions
Regulation of reproductive physiologyGnRH releaseGonadotropin secretionMetabolic regulation
04
Disease associations
Isolated hypogonadotropic hypogonadismPuberty disordersFertility disordersMetastasis in malignant melanomasBreast carcinoma
05
Interacting drugs
TAK448
1 more in the full profile.
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