Kisspeptin protein (KP (or KISS1, depending on context))

Kisspeptin is a family of peptide hormones encoded by the KISS1 gene, with key forms including kisspeptin-54 and shorter peptides like kisspeptin-10. Kisspeptins are endogenous ligands of the G protein-coupled receptor KISS1R (GPR54). Originally discovered as a metastasis-suppressor (metastin), kisspeptin is now recognized for its role as a central regulator of puberty onset and fertility through stimulation of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus, thus controlling pituitary release of LH and FSH and downstream sexual maturation[1][2][3][6][7]. Kisspeptin/KISS1R signaling also has roles in cancer biology (especially triple-negative breast cancer), metastasis suppression, and potentially metabolic regulation[4][10]. Therapeutic analogs and receptor antagonists/agonists are under investigation for disorders of puberty, infertility, and certain cancers, as well as for possible use as contraceptives[2][6][9].

Other names

metastinKISS1-derived peptideskisspeptin-54KP-54kisspeptin-10kisspeptin-13kisspeptin-14

stimulation or inhibition of GnRH secretion by acting as an endogenous ligand for GPR54/KISS1R (a G protein-coupled receptor), leading to downstream pituitary hormone (LH, FSH) release and regulation of sex steroid production[2][6][7][9]