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Target intelligence / Profile preview
KIT (Stem Cell Growth Factor Receptor) (KIT)
- Target
- KIT
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
KIT, also known as the stem cell growth factor receptor or CD117, is a receptor tyrosine kinase that plays a crucial role in cell proliferation, survival, migration, and differentiation. It is essential for the development and function of hematopoietic stem cells, germ cells, mast cells, interstitial cells of Cajal, and melanocytes. Gain-of-function mutations in KIT are associated with several human cancers, including gastrointestinal stromal tumors, acute myelogenous leukemia, and mastocytomas. KIT serves as an important drug target, especially in oncology, for small molecule inhibitors like imatinib, which are effective against certain activating mutations.
- Other names
- Stem Cell Growth Factor ReceptorCD117c-KIT
02
Mechanism of action
Small molecule inhibitor that binds inactive conformation at ATP-binding site of mutant Kit proteins.
03
Biological functions
Cell proliferationSurvivalMigrationDifferentiationHematopoiesisGametogenesisMelanogenesisSignal transduction
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)Acute myelogenous leukemiaMastocytomas
05
Safety considerations
Resistance to imatinib due to secondary mutationsOff-target effects of kinase inhibitors
06
Interacting drugs
1 more in the full profile.
07
Biomarkers
KIT mutations (e.g., V559D, T670I, L576P, D816V, A829P)
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