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Target intelligence / Profile preview
KIT Proto-Oncogene Receptor Tyrosine Kinase (KIT)
- Target
- KIT
- Molecular classification
- Receptor Tyrosine Kinase, Type III Receptor, Proto-oncogene
01
Overview
KIT is a type III receptor tyrosine kinase that acts as a cell-surface receptor for stem cell factor (SCF). Upon SCF binding, it dimerizes and activates its intrinsic tyrosine kinase activity, regulating key cellular processes such as cell survival, proliferation, differentiation, and migration. Mutated forms are implicated in various cancers, particularly GIST, making it a therapeutic target for tyrosine kinase inhibitors.
- Other names
- c-KITCD117SCFRstem cell factor receptormast/stem cell growth factor receptor
02
Mechanism of action
Tyrosine kinase inhibitors specifically inhibit mutant or overactive forms of c-KIT.
03
Biological functions
Cell survivalProliferationDifferentiationMigrationSignal transduction
04
Disease associations
CancerGastrointestinal Stromal Tumor (GIST)MastocytosisAcute Myeloid LeukemiaMelanomaBreast CancerThyroid CancerColorectal CancerPiebaldism
05
Safety considerations
Drug resistance due to specific mutationsVariable drug sensitivity based on mutation profileAltered degradation kinetics of mutants
06
Interacting drugs
07
Biomarkers
KIT mutations (e.g., in GIST)KIT overexpression
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