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Target intelligence / Profile preview
Klebsiella pneumoniae Capsular Polysaccharide (CPS)
- Target
- CPS
- Molecular classification
- Polysaccharide, Capsule, Glycan
01
Overview
Klebsiella pneumoniae capsular polysaccharide is a structurally diverse extracellular carbohydrate essential for virulence due to its roles in immune evasion and environmental adaptation. Its biosynthesis involves complex genetic loci encoding multiple enzymes responsible for assembly/export. Because it is both highly immunogenic yet variable between strains—and crucial to pathogenesis—it remains both a challenge and opportunity as a therapeutic/vaccine target against multidrug-resistant K. pneumoniae.
- Other names
- K. pneumoniae CPSCapsular PolysaccharideK antigencps locus productK locus product
02
Mechanism of action
Glycoconjugate vaccines: Induce serotype-specific antibody production to promote opsonization and phagocytosis. Phage-derived depolymerases: Degrade the capsule, rendering bacteria susceptible to immune clearance and antibiotics.
03
Biological functions
Immune evasionAnti-phagocytosisSerum resistanceBiofilm formationAdherenceProtection from environmental stress
04
Disease associations
InfectionPneumoniaSepsisUrinary tract infectionLiver abscessMulti-drug resistance
05
Safety considerations
Serotype variability complicates vaccine development.Potential for immune response to cross-reactive CPS serotypes.Emergence of new CPS serotypes.
06
Interacting drugs
Glycoconjugate vaccines (serotype-specific)
2 more in the full profile.
07
Biomarkers
CPS serotype (for vaccine development and epidemiological studies)CPS production levels (correlated with virulence)
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