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Target intelligence / Profile preview
Klotho Protein (KL)
- Target
- KL
- Molecular classification
- Type I transmembrane protein, Glycoprotein, Co-receptor, Hormone
01
Overview
The Klotho protein is a type I transmembrane glycoprotein predominantly produced in the kidney and expressed in other tissues. It functions as a co-receptor for FGF23, regulating mineral metabolism. It is considered an anti-aging factor and has anti-inflammatory and antioxidant properties. Soluble Klotho serves as a biomarker for aging, kidney function, and inflammation, and is being explored as a potential therapeutic target.
- Other names
- α-KlothoKLKlotho
02
Mechanism of action
Acts as a co-receptor for FGF23, regulating phosphate excretion, vitamin D metabolism, and calcium reabsorption. Modulates ion channel activity. Inhibits insulin/IGF-1 and Wnt signaling pathways. Activates antioxidant pathways and suppresses inflammation.
03
Biological functions
Regulation of mineral metabolismFGF23 co-receptor activityAnti-agingInsulin/IGF-1 signaling inhibitionWnt signaling suppressionAnti-inflammatory effectsAntioxidant effects
04
Disease associations
Chronic kidney diseaseCardiovascular diseaseType II diabetes mellitusHypertensionCognitive declineDementiaCancerAging
05
Safety considerations
Lowered Klotho levels associated with increased risk of age-related diseasesPotential for off-target effects when manipulating Klotho levels
06
Biomarkers
Soluble α-Klotho levels
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