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Target intelligence / Profile preview
Klotho Beta (KLB)
- Target
- KLB
- Molecular classification
- Single-pass transmembrane protein, Glycoside hydrolase family 1 superfamily, Co-receptor
01
Overview
Klotho beta (KLB) is a single-pass transmembrane protein that functions as an obligatory co-receptor for the endocrine fibroblast growth factors FGF19 and FGF21. It plays a critical role in regulating bile acid synthesis, glucose homeostasis, lipid metabolism, and energy expenditure. KLB primarily acts by forming complexes with FGFRs upon binding with FGF19 or FGF21, triggering downstream signaling cascades. Its involvement in metabolic regulation makes it a potential therapeutic target, with mimetics of its ligands showing promise in clinical trials.
- Other names
- KLOTBBeta-Klotho
02
Mechanism of action
KLB acts as an essential co-receptor for certain endocrine fibroblast growth factors, notably FGF19 and FGF21, facilitating their binding to FGFRs and subsequent downstream signaling involved in metabolic regulation.
03
Biological functions
FGF receptor bindingRegulation of bile acid synthesisModulation of glucose homeostasisModulation of lipid metabolismRegulation of energy expenditureSignal transduction
04
Disease associations
Hypogonadotropic hypogonadismMale infertilityFunctional diarrheaMetabolic disorders
05
Safety considerations
Potential for off-target effects due to broad tissue expressionLong-term effects of modulating FGF signaling pathways
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