KN motif and ankyrin repeat domains 2 (KANK2)

KN motif and ankyrin repeat domains 2 (KANK2) is a scaffold protein of the KANK family, characterized by a KN motif and multiple ankyrin repeats[1][4][5]. KANK2 functions as a regulator of cytoskeletal formation by modulating actin polymerization and interacting with key regulators of the Rho GTPase signaling pathway, such as ARHGDIA, to maintain proper cell structure and migration, especially in specialized cells like kidney podocytes[1][4]. KANK2 also sequesters steroid receptor coactivators in the cytoplasm, thereby indirectly regulating nuclear hormone receptor signaling (including the vitamin D receptor)[2][3][4]. Mutations in KANK2 are associated with genetic disorders such as steroid-resistant nephrotic syndrome and palmoplantar keratoderma with woolly hair, highlighting its tissue-specific role in the kidney and skin[3][4]. KANK2 acts as an adaptor linking integrin-containing focal adhesions to microtubule networks, further influencing cell adhesion, migration, and response to cytoskeletal drugs[1][4][5]. There are currently no approved small molecule drugs or biologics specifically targeting KANK2, and the protein is not classified as a common therapeutic drug target (receptor, enzyme, transporter, etc.) in current medical practice.

Other names

SRC-interacting proteinSIPANKRD25KIAA1518Matrix-remodeling-associated protein 3MXRA3NPHS16PPKWH

null