Target intelligence / Profile preview

Krüppel-like factor 4 (KLF4)

Target: KLF4
Molecular classification: Transcription factor, SP/KLF family

Overview

KLF4 is an evolutionarily conserved transcription factor characterized by three C2H2-type zinc fingers. It acts both as an activator/repressor depending on context. It regulates key processes like cell cycle arrest/differentiation/self-renewal/apoptosis/stemness. Its dysregulation contributes to various diseases including cancers where it may act either as tumor suppressor or oncogene based on tissue type/contextual cues. It is one of the four Yamanaka factors essential for iPSC generation—a hallmark role linking it directly with regenerative medicine applications.

Other names: GKLFgut-enriched Krüppel-like factor

Biological functions

Cell growthCell proliferationCell differentiationApoptosisSomatic cell reprogrammingCell cycle regulationStem cell self-renewal

Disease associations

CancerHematologic cancersGliomaInflammation

Safety considerations

Dual role as tumor suppressor or oncogene depending on cellular context

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