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Target intelligence / Profile preview
KRAS Gly12Cys (KRAS G12C)
- Target
- KRAS G12C
- Molecular classification
- Small GTPase, Oncogene
01
Overview
KRAS G12C is a specific mutation in the KRAS gene, where glycine at codon 12 is replaced by cysteine. This mutation causes the K-Ras protein to become constitutively active, driving uncontrolled cell growth and contributing to tumorigenesis, particularly in non-small cell lung cancer, colorectal cancer and other solid tumors. It is a target for small molecule inhibitors like sotorasib and adagrasib.
- Other names
- KRAS p.Gly12CysKRAS c.34G>TKRAS Gly12CK-Ras G12C
02
Mechanism of action
Covalent binding to the cysteine residue introduced by the G12C mutation, inhibiting KRAS G12C activity.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survival
04
Disease associations
CancerNon-small cell lung cancer (NSCLC)Colorectal cancerSolid tumors
05
Safety considerations
Resistance developmentOff-target effectsDrug interactions
06
Interacting drugs
Sotorasib
1 more in the full profile.
07
Biomarkers
KRAS G12C mutation status
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