KRR1 small subunit processome component homolog (KRR1)

KRR1 small subunit processome component homolog (KRR1) is a conserved RNA-binding protein required for ribosomal small subunit biogenesis and is essential for cell viability[1][2][3]. Located primarily in the nucleolus, KRR1 facilitates processing of precursor ribosomal RNA (pre-rRNA), particularly for 18S rRNA synthesis and the assembly of the 40S ribosomal subunit[1][2]. The protein is part of the small subunit (SSU) processome, where it interacts with other ribosome biogenesis factors, RNA chaperones, and ribosomal proteins to guide RNA folding, modifications, cleavages, and degradation of pre-ribosomal RNA[2]. KRR1 exhibits high evolutionary conservation and is most abundantly expressed in dividing cells, with its synthesis closely linked to cellular growth rate[1]. Genetic studies in yeast demonstrate that depletion of KRR1 leads to defects in 18S rRNA maturation, reduced levels of 40S subunits, and cell death[1]. Although KRR1 has been proposed as a "Rev-interacting protein" and "HIV-1 Rev-binding protein 2," there is no confirmed evidence for a direct role in viral pathogenesis or as a therapeutic target in humans[2][3][4]. Diseases genetically associated with KRR1 include Dystonia 35 and duodenum adenoma, though mechanisms are not fully elucidated[2].

Other names

HRB2RIP-1HIV-1 Rev-binding protein 2KRR-R motif-containing protein 1Rev-interacting protein 1small subunit processome componentKRR1 small subunit processome component homolog