Krueppel-like factor 13 (KLF13)

Krueppel-like factor 13 (KLF13) is a zinc finger transcription factor of the SP1-like/Kruppel-like factor family, characterized by three C2H2-type zinc finger domains enabling DNA binding to GC-rich CACCC motifs. It plays critical roles in the regulation of gene expression across multiple tissues, notably in cardiac morphogenesis by cooperating with GATA-4 in early heart development, activation and survival of T lymphocytes (where it regulates RANTES and Bcl-xL expression), erythroid differentiation by activating gamma-globin transcription, and modulation of immune and inflammatory processes including macrophage activation. KLF13 also influences cell cycle progression and protects neurons from excitotoxic damage. Dysregulation of KLF13 has been associated with congenital heart disease, obesity, immune dysfunction, and certain cancers, emphasizing its context-specific regulatory functions.

Other names

BTEB3NSLP1RFLAT-1FKLF-2Basic transcription element-binding protein 3Novel Sp1-like zinc finger transcription factor 1RANTES factor of late activated T-lymphocytes 1Transcription factor BTEB3Transcription factor NSLP1FKLF2RFLAT1Kruppel like factor 13BTE-binding protein 3basic transcription element binding protein 3

Drugs/molecules regulating KLF13 typically act via modulation of microRNA expression (e.g., miR-125a-5p, miR-125b-5p). Transcriptional modulation or indirect effects via pathways such as glucocorticoid signaling.