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Target intelligence / Profile preview
Kruppel-like factor 5 (KLF5)
- Target
- KLF5
- Molecular classification
- Transcription factor
01
Overview
Kruppel-like factor 5 (KLF5) is a transcription factor that plays a role in cell proliferation and differentiation by regulating the expression of genes involved in these processes. It is known to interact with co-activators like CBP to enhance its transactivation function, and its activity can be modulated by phosphorylation. KLF5 is involved in tumorigenesis and has been implicated in the regulation of genes such as cyclin D1 and cyclin B1, which are crucial for cell cycle progression. Its expression is often increased in transformed cells and can be influenced by various signaling pathways, including oncogenic H-Ras signaling.
- Other names
- Intestine-enriched Kruppel-like factor (IKLF)Basic transcription element binding protein 2 (Bteb2)
02
Mechanism of action
Regulation of target gene expression through binding to GC-rich DNA sequences; interaction with co-activators like CBP enhances its transactivation function
03
Biological functions
Cell proliferationdifferentiationdevelopmentregulation of gene transcription
04
Disease associations
Cancertumorigenesis
05
Safety considerations
Overexpression can lead to increased cell proliferation and transformation, potentially contributing to cancer development
06
Biomarkers
Elevated expression in some cancer cells, particularly in oncogenic H-Ras transformed cells
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