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Target intelligence / Profile preview
Kynurenine Aminotransferase II (KAT II)
- Target
- KAT II
- Molecular classification
- Enzyme, Aminotransferase, Pyridoxal 5'-phosphate (PLP)-dependent enzyme, Fold type I aminotransferase, Subgroup Iepsilon aminotransferase
01
Overview
Kynurenine aminotransferase II (KAT II) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that plays a crucial role in the kynurenine pathway of tryptophan metabolism. This enzyme catalyzes the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an endogenous antagonist of N-methyl-D-aspartate (NMDA) receptors and alpha 7-nicotinic acetylcholine receptors. KAT II is considered the primary isoform responsible for KYNA synthesis in the mammalian brain, mainly active in astrocytes. Abnormal KYNA levels have been implicated in neurological disorders such as schizophrenia and Alzheimer's disease.
- Other names
- Aminoadipate aminotransferase
02
Mechanism of action
Inhibition of Kynurenine Aminotransferase II to modulate KYNA levels
03
Biological functions
Kynurenine metabolismKynurenic acid (KYNA) synthesisLysine metabolismTransamination
04
Disease associations
SchizophreniaAlzheimer's diseaseOther neurological disorders
05
Safety considerations
Altering KYNA levels may have unintended consequences on glutamatergic neurotransmission and neuroprotection.
06
Biomarkers
KYNA levels in the brain
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