L-alanine transaminase (ALT)

L-alanine transaminase (ALT), also known as alanine aminotransferase, is an enzyme that catalyzes the reversible transfer of an amino group from L-alanine to α-ketoglutarate, producing pyruvate and L-glutamate. ALT is predominantly found in the liver, making it a key biomarker for liver health. Elevated serum ALT levels are indicative of hepatocellular injury or liver disease. The enzyme requires pyridoxal phosphate as a coenzyme. While ALT itself is not directly targeted by drugs, its levels are monitored to assess the impact of drugs and other factors on liver function.

Other names

Alanine transaminaseAlanine aminotransferaseSerum glutamate-pyruvate transaminaseGPTSGPTALAT

Not applicable - ALT is primarily a biomarker, not a direct drug target, though drugs can affect its levels through liver effects.