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L Antigen Family Member 1a (None)
- Target
- None
- Molecular classification
- Cancer/Testis Antigen, ESO/LAGE family
01
Overview
L Antigen Family Member 1a (LAGE-1a) is a tumor-associated antigen belonging to the ESO/LAGE family of cancer-testis antigens. It is encoded by the CTAG2 gene and exhibits restricted expression primarily in cancerous tissues and testicular germ cells, making it a target for cancer immunotherapy. LAGE-1a can elicit immune responses and is being explored for targeted therapies such as therapeutic vaccines or adoptive T-cell therapies.
- Other names
- LAGE-1aCancer/Testis Antigen 2CTAG2
02
Mechanism of action
Therapeutic vaccines or adoptive T-cell therapies aimed at treating cancers expressing this antigen
03
Biological functions
Tumor-associated antigenEliciting T-cell mediated immunityTarget for cancer immunotherapy
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects if expression is not completely restricted to tumor and testis tissuesRisk of autoimmunity
06
Biomarkers
LAGE-1a expression in tumors
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