L antigen family member 3 pseudogene 1 (LAGE3P1)

L antigen family member 3 pseudogene 1 (LAGE3P1) is annotated as a **pseudogene** and does not encode a functional protein product[1]. Pseudogenes are genomic DNA sequences similar to normal genes but are nonfunctional; they typically arise from duplication or retrotransposition but lack essential regulatory or coding capacity[2][4]. LAGE3P1 is related by sequence homology to L antigen family member 3 (LAGE3), which itself is a bona fide protein-coding gene involved in the KEOPS complex and implicated as a biomarker and modulator in various cancers[3][5]. However, LAGE3P1, as a pseudogene, does not have verified biological function, molecular activity, or disease role and is not considered a therapeutic target[1].\n\n**Key context:** \n- LAGE3P1 is not a functional protein, receptor, enzyme, or therapeutic target based on current human genome annotation[1].\n- Pseudogenes can, in rare cases, have non-coding regulatory functions (e.g., acting as miRNA sponges), but there is no evidence LAGE3P1 specifically has such a role in disease or therapy[2].\n- The functional, disease-relevant protein is L antigen family member 3 (LAGE3), not LAGE3P1[3].\n\nIf you are seeking information about a **true protein-coding gene** implicated in cancer and potential therapeutic targeting, you may be referring to **L antigen family member 3 (LAGE3)** rather than LAGE3P1.