Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
L-glutamate transporter (EAATs (for sodium-dependent glutamate transporters), VGLUTs (for vesicular glutamate transporters))
- Target
- EAATs (for sodium-dependent glutamate transporters), VGLUTs (for vesicular glutamate transporters)
- Molecular classification
- Transporter
01
Overview
L-glutamate transporters are proteins responsible for regulating glutamate concentrations in the extracellular space by transporting glutamate across cell membranes. They are crucial for terminating excitatory signals and preventing excitotoxicity in the central nervous system. The two main classes are sodium-dependent glutamate transporters (EAATs) and vesicular glutamate transporters (VGLUTs). EAATs are primarily found on astrocytes and neurons, while VGLUTs are located in synaptic vesicles. Dysregulation of these transporters is implicated in various neurological disorders.
- Other names
- Excitatory amino acid transporters (EAATs)Vesicular glutamate transporters (VGLUTs)Cystine-glutamate antiporter (xCT)
02
Mechanism of action
Modulation of glutamate uptake to prevent excitotoxicity and regulate neurotransmitter levels
03
Biological functions
Regulation of neurotransmitter levelstermination of excitatory signalsprevention of excitotoxicity
04
Disease associations
Neurodegenerative diseases (e.g., Alzheimer's disease, ALS)EpilepsyStrokeMovement disorders
05
Safety considerations
Potential for excitotoxicity if transporters are dysfunctionaltherapeutic challenges include maintaining optimal glutamate levels
06
Interacting drugs
Ceftriaxone (a GLT-1 translational activator)
07
Biomarkers
None specifically identified for glutamate transporters, but changes in glutamate levels or transporter expression might serve as biomarkers
Beyond the preview
Go deeper on L-glutamate transporter (EAATs (for sodium-dependent glutamate transporters), VGLUTs (for vesicular glutamate transporters)).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on L-glutamate transporter (EAATs (for sodium-dependent glutamate transporters), VGLUTs (for vesicular glutamate transporters)).