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Glutamine is a nonessential amino acid that becomes conditionally essential during periods of stress. It plays vital roles in protein synthesis, metabolism, immune function, and intestinal health. While the body can typically produce sufficient amounts, supplementation may be beneficial in specific clinical scenarios such as sickle cell disease and recovery from severe physical stress. It functions as a nitrogen and carbon donor, participates in acid-base regulation, and supports rapidly dividing cells, particularly lymphocytes and enterocytes.
As a supplement, glutamine may support overall protein synthesis, immune function, and gut barrier function, and reduce sickling of red blood cells (Endari).
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