Target intelligence / Profile preview

Glutamine (Gln)

Target
Gln
Molecular classification
Amino Acid, Nonessential Amino Acid (conditionally essential)
01

Overview

Glutamine is a nonessential amino acid that becomes conditionally essential during periods of stress. It plays vital roles in protein synthesis, metabolism, immune function, and intestinal health. While the body can typically produce sufficient amounts, supplementation may be beneficial in specific clinical scenarios such as sickle cell disease and recovery from severe physical stress. It functions as a nitrogen and carbon donor, participates in acid-base regulation, and supports rapidly dividing cells, particularly lymphocytes and enterocytes.

Other names
QL-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid
02

Mechanism of action

As a supplement, glutamine may support overall protein synthesis, immune function, and gut barrier function, and reduce sickling of red blood cells (Endari).

03

Biological functions

Protein synthesisNitrogen donorCarbon donorAmmonia transportImmune supportIntestinal healthAcid-base regulation
04

Disease associations

Sickle cell diseaseCritical illnessBurn recoverySurgical recoveryHIV/AIDS complications (potential)
05

Safety considerations

Generally considered safe but excessive intake may cause gastrointestinal distress.Potential interactions with medications; consult healthcare provider before supplementing, especially in individuals with kidney or liver disease.
06

Interacting drugs

Endari (prescription L-glutamine)

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